Whitening effect of alpha-bisabolol in Asian women subjects

Int J Cosmet Sci. 2010 Aug;32(4):299-303. doi: 10.1111/j.1468-2494.2010.00560.x.


Although skin pigmentation, which results from the production and distribution of melanin in the epidermis, is the major physiological defence against solar irradiation, hyperpigmentation is a common and distressing problem caused by various inflammatory skin disorders, such as eczema, allergic contact dermatitis and irritant contact dermatitis. We evaluated the effects of a preparation containing alpha-bisabolol on pigmented skin of a group of subjects. The effectiveness of the active compound, alpha-bisabolol, in a base-cream preparation for the treatment of pigmented skin was tested on 28 female subjects as follows: the cream was applied once a day to the back for 8 weeks. These same women also applied a vehicle control cream to the pigmented skin. The results were evaluated by clinical and biophysical test methods. After 8 weeks of treatment of the alpha-bisabolol-containing cream, there was significant lightening effect in the pigmented skin for the majority of the subjects who tested the cream.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Topical
  • Adult
  • Asian People
  • Cosmetics / administration & dosage
  • Cosmetics / pharmacology*
  • Double-Blind Method
  • Female
  • Humans
  • Middle Aged
  • Monocyclic Sesquiterpenes
  • Sesquiterpenes / administration & dosage
  • Sesquiterpenes / pharmacology*
  • Skin Pigmentation / drug effects
  • Skin Pigmentation / physiology*
  • Spectrophotometry


  • Cosmetics
  • Monocyclic Sesquiterpenes
  • Sesquiterpenes
  • bisabolol