Type IV secretion systems: versatility and diversity in function

Cell Microbiol. 2010 Sep 1;12(9):1203-12. doi: 10.1111/j.1462-5822.2010.01499.x. Epub 2010 Jul 16.

Abstract

Type IV secretion systems (T4SSs) are large protein complexes which traverse the cell envelope of many bacteria. They contain a channel through which proteins or protein-DNA complexes can be translocated. This translocation is driven by a number of cytoplasmic ATPases which might energize large conformational changes in the translocation complex. The family of T4SSs is very versatile, shown by the great variety of functions among family members. Some T4SSs are used by pathogenic Gram-negative bacteria to translocate a wide variety of virulence factors into the host cell. Other T4SSs are utilized to mediate horizontal gene transfer, an event that greatly facilitates the adaptation to environmental changes and is the basis for the spread of antibiotic resistance among bacteria. Here we review the recent advances in the characterization of the architecture and mechanism of substrate transfer in a few representative T4SSs with a particular focus on their diversity of structure and function.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism*
  • Bacterial Secretion Systems*
  • Biological Transport
  • Conjugation, Genetic
  • DNA, Bacterial / metabolism
  • Gram-Negative Bacteria / genetics
  • Gram-Negative Bacteria / metabolism*
  • Gram-Negative Bacteria / pathogenicity
  • Gram-Positive Bacteria / genetics
  • Gram-Positive Bacteria / metabolism*
  • Gram-Positive Bacteria / pathogenicity
  • Humans
  • Virulence Factors / genetics
  • Virulence Factors / metabolism*

Substances

  • Bacterial Proteins
  • Bacterial Secretion Systems
  • DNA, Bacterial
  • T-DNA
  • Virulence Factors