Evidence for a dose-dependent effect of pulsed magnetic fields on pain processing

Neurosci Lett. 2010 Sep 27;482(2):160-2. doi: 10.1016/j.neulet.2010.07.024. Epub 2010 Jul 17.


Functional magnetic resonance imaging (fMRI) was used to investigate the dose-response relationship (sham, 100, 200, 1000 microT) between a pulsed extremely low frequency magnetic field (ELFMF) and acute thermal pain on the dominant right hand. Forty-seven participants were recruited, and pulsed ELFMF was applied through the MRI gradient system using a novel technique. Regions of interest (ROIs) matching those of previous studies were examined for a potential dose response. Significant correlations between applied field strength and change in BOLD activity were found in the anterior cingulate and the ipsilateral insula, indicating that there might be either a dose response or a threshold effect of the ELFMF.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Disease
  • Adult
  • Brain / physiopathology
  • Brain / radiation effects*
  • Brain Mapping
  • Dose-Response Relationship, Radiation
  • Electromagnetic Fields*
  • Humans
  • Magnetic Resonance Imaging
  • Pain / physiopathology*
  • Pain Perception
  • Temperature
  • Young Adult