Treatment of cutaneous sarcoidosis with chloroquine. Review of the literature

Arch Dermatol. 1991 Jul;127(7):1034-40.


Systemic corticosteroids may be either contraindicated or not efficacious in treating the cutaneous manifestations occurring in 20% to 35% of patients with systemic sarcoidosis. Chloroquine phosphate has been reported to be a valuable alternative therapy for cutaneous lesions of sarcoidosis. With a judiciously determined daily dosage and regular 6-month ophthalmologic follow-up examinations, the risk of developing retinopathy can be avoided, because the daily dosage rate rather than total dose accumulation determines the development of chloroquine-induced retinopathy. We reviewed the efficacy and safety of chloroquine and its role in the treatment of cutaneous sarcoidosis.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Chloroquine / adverse effects
  • Chloroquine / therapeutic use*
  • Humans
  • Sarcoidosis / drug therapy*
  • Skin Diseases / drug therapy*


  • Chloroquine