Trans fatty acids and weight gain

Int J Obes (Lond). 2011 Mar;35(3):315-24. doi: 10.1038/ijo.2010.141. Epub 2010 Jul 20.


Increasing rates of obesity have stimulated research into possible contributing factors, including specific dietary components such as trans fatty acids (TFAs). This review considers the evidence for an association between TFA intake and weight gain. It concludes that there is limited but consistent evidence from epidemiological studies, and from a primate model, that increased TFA consumption may result in a small additional weight gain. Data from a long-term study in a primate model suggest that TFA may have a greater adipogenic effect than cis monounsaturated fatty acids; however, there are currently inadequate mechanistic data to provide a comprehensive and plausible explanation for any such metabolic differences between the types of fatty acids.

Publication types

  • Review

MeSH terms

  • Adipogenesis / physiology
  • Animals
  • Chlorocebus aethiops
  • Diet
  • Dietary Fats / adverse effects
  • Dietary Fats / metabolism*
  • Humans
  • Insulin Resistance / physiology*
  • Obesity / metabolism*
  • Rats
  • Risk Factors
  • Trans Fatty Acids / adverse effects
  • Trans Fatty Acids / metabolism*
  • Weight Gain / physiology*


  • Dietary Fats
  • Trans Fatty Acids