Anti-scratching behavioral effect of the essential oil and phytol isolated from Artemisia princeps Pamp. in mice

Planta Med. 2011 Jan;77(1):22-6. doi: 10.1055/s-0030-1250119. Epub 2010 Jul 19.


The anti-scratching behavioral effect of the essential oil and phytol isolated from Artemisia princeps Pamp. (AP, family Asteraceae), which is widely used in traditional medicine for inflammatory diseases, was investigated IN VIVO. Treatment of mice with AP essential oil (APEO) and phytol inhibited histamine- and compound 48/80-induced scratching behaviors. The anti-scratching behavioral effects of APEO and phytol are in proportion to their vascular permeability-inhibitory effects. These agents also inhibited the level of allergic cytokines, IL-4, and TNF- α, and the activation of transcription factors, NF- κB and c-jun (AP-1), in histamine-treated skin tissues. Based on these results, APEO and phytol may improve scratching behavior in skin by inhibiting the expression of allergic cytokines via the regulation of NF- κB and AP-1 activation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antipruritics / chemistry
  • Antipruritics / pharmacology*
  • Antipruritics / therapeutic use
  • Asteraceae / chemistry*
  • Enzyme Activation / drug effects
  • Interleukin-4 / metabolism
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred ICR
  • NF-kappa B / metabolism
  • Oils, Volatile / chemistry
  • Oils, Volatile / pharmacology*
  • Oils, Volatile / therapeutic use
  • Phytol / chemistry
  • Phytol / pharmacology*
  • Phytol / therapeutic use
  • Plant Oils / chemistry
  • Plant Oils / pharmacology*
  • Plant Oils / therapeutic use
  • Pruritus / drug therapy*
  • Transcription Factor AP-1 / metabolism
  • Tumor Necrosis Factor-alpha / metabolism


  • Antipruritics
  • NF-kappa B
  • Oils, Volatile
  • Plant Oils
  • Transcription Factor AP-1
  • Tumor Necrosis Factor-alpha
  • Phytol
  • Interleukin-4