A case of pressure ulcer in a 25-year-old male patient with the neurodegenerative disorder giant axonal neuropathy (GAN) was safely and effectively treated with an eight-week regimen of oxandrolone and nutritional supplementation. An initial dose of 5 mg twice daily was begun for the first two weeks of therapy, followed by six weeks of treatment with 10 mg twice daily. This therapy was supported with protein supplementation and adequate caloric intake. The patient's liver function tests were monitored weekly and remained within the normal range. His pressure ulcer was completely resolved at the conclusion of the eight weeks of therapy.