Hypolipidemic effect of fucoidan from Laminaria japonica in hyperlipidemic rats

Pharm Biol. 2010 Apr;48(4):422-6. doi: 10.3109/13880200903150435.

Abstract

In this study, we investigated the effect of fucoidan polysaccharide sulfuric acid ester (FPS) from Laminaria japonica Aresch (Laminariaceae) on hyperlipidemic rats. FPS notably reduced the concentration of serum total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C) of hyperlipidemic rats and increased the concentration of high-density lipoprotein cholesterol (HDL-C) and the activities of lipoprotein lipase (LPL), hepatic lipoprotein (HL), and lecithin cholesterol acyltransferase (LCAT).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Dietary Fats / administration & dosage
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Hyperlipidemias / blood
  • Hyperlipidemias / drug therapy*
  • Hypolipidemic Agents / isolation & purification
  • Hypolipidemic Agents / therapeutic use*
  • Laminaria / chemistry*
  • Lipids / blood
  • Male
  • Polysaccharides / isolation & purification
  • Polysaccharides / therapeutic use*
  • Rats
  • Rats, Sprague-Dawley

Substances

  • Dietary Fats
  • Hypolipidemic Agents
  • Lipids
  • Polysaccharides
  • fucoidan