Abstract
This study evaluated possible CNS effects of a hexane extract of leaves from Rollinia mucosa (Jacq.) Baill. (Annonaceae). This plant extract induced anxiolytic-like actions similar to those induced by diazepam in the avoidance exploratory behavior paradigm. Its significant activity was shown at doses from 1.62 to 6.25 mg/kg. It also enhanced pentobarbital-induced hypnosis time, and at high doses produced motor coordination impairment. The benzodiazepine (BDZ) receptor binding, evaluated by in vitro autoradiography following a single administration of R. mucosa, revealed that this plant extract reduced BDZ binding in the hippocampus (29%), amygdala (26%), and temporal cortex of mice (36%). In conclusion, the present findings support the proposal that R. mucosa may induce central nervous system (CNS) depressant effects, presumably through an interaction with the GABA/benzodiazepine receptor complex.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Anxiety Agents / isolation & purification
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Anti-Anxiety Agents / pharmacology*
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Anti-Anxiety Agents / therapeutic use
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Anxiety / drug therapy
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Dose-Response Relationship, Drug
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Drug Synergism
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Exploratory Behavior / drug effects
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Exploratory Behavior / physiology
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Hypnotics and Sedatives / isolation & purification
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Hypnotics and Sedatives / pharmacology*
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Hypnotics and Sedatives / therapeutic use
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Male
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Mice
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Motor Activity / drug effects
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Motor Activity / physiology
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Pentobarbital / pharmacology
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Pentobarbital / therapeutic use
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology*
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Plant Extracts / therapeutic use
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Receptors, GABA / physiology*
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Receptors, GABA-A / physiology*
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Rollinia*
Substances
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Anti-Anxiety Agents
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Hypnotics and Sedatives
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Plant Extracts
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Receptors, GABA
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Receptors, GABA-A
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Pentobarbital