Nootropic activity of Celastrus paniculatus seed

Pharm Biol. 2010 Mar;48(3):324-7. doi: 10.3109/13880200903127391.


The effect of Celastrus paniculatus Willd. (Celastraceae) seed aqueous extract on learning and memory was studied using elevated plus maze and passive avoidance test (sodium nitrite induced amnesia rodent model). The aqueous seed extract was administered orally in two different doses to rats (350 and 1050 mg/kg) and to mice (500 and 1500 mg/kg). The results were compared to piracetam (100 mg/kg, p.o.) used as a standard drug. Chemical hypoxia was induced by subcutaneous administration of sodium nitrite (35 mg/kg), immediately after acquisition training. In elevated plus maze and sodium nitrite-induced amnesia model, Celastrus paniculatus extract has showed statistically significant improvement in memory process when compared to control. The estimation of acetylcholinesterase enzyme in rat brain supports the plus maze and passive avoidance test by reducing acetylcholinesterase activity which helps in memory performance. The study reveals that the aqueous extract of Celastrus paniculatus seed has dose-dependent cholinergic activity, thereby improving memory performance. The mechanism by which Celastrus paniculatus enhances cognition may be due to increased acetylcholine level in rat brain.

MeSH terms

  • Acetylcholinesterase / metabolism
  • Amnesia, Retrograde / chemically induced
  • Amnesia, Retrograde / metabolism
  • Amnesia, Retrograde / prevention & control
  • Animals
  • Brain / drug effects
  • Brain / enzymology
  • Celastrus / chemistry*
  • Dose-Response Relationship, Drug
  • Female
  • Learning / drug effects*
  • Male
  • Medicine, Ayurvedic
  • Memory / drug effects*
  • Mice
  • Neurons / drug effects
  • Neurons / enzymology
  • Nootropic Agents / administration & dosage
  • Nootropic Agents / therapeutic use*
  • Phytotherapy*
  • Plant Extracts / administration & dosage
  • Plant Extracts / therapeutic use*
  • Random Allocation
  • Rats
  • Rats, Wistar
  • Seeds / chemistry*


  • Nootropic Agents
  • Plant Extracts
  • Acetylcholinesterase