Understanding the molecular mechanism of protein translocation across the mitochondrial inner membrane: still a long way to go

Biochim Biophys Acta. 2011 Mar;1808(3):990-1001. doi: 10.1016/j.bbamem.2010.07.011. Epub 2010 Jul 18.


In order to reach the final place of their function, approximately half of the proteins in any eukaryotic cell have to be transported across or into one of the membranes in the cell. In this article, we present an overview of our current knowledge concerning the structural properties of the TIM23 complex and their relationship with the molecular mechanism of protein transport across the mitochondrial inner membrane. This article is part of a Special Issue entitled Protein translocation across or insertion into membranes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Humans
  • Mitochondria / metabolism*
  • Mitochondrial Membranes / metabolism*
  • Mitochondrial Proteins / metabolism*
  • Protein Transport


  • Mitochondrial Proteins