Nuclear Pore Protein p62 Autoantibodies in Systemic Lupus Erythematosus

Open Rheumatol J. 2010 May 13;4:24-7. doi: 10.2174/1874312901004010024.


Systemic lupus erythematosus (SLE) is a systemic autoimmune disease which is classically characterised by a variety of autoantibodies to deoxyribonucleic acid (DNA), ribonucleic acid (RNA), other nuclear and cytoplasmic antigens. Recently several novel autoantibodies against a variety of specific nuclear pore proteins have been described, including the nucleoporin p62. In this paper we evaluate anti-nucleoporin p62 antibodies by western blot analysis in 25 systemic lupus erythematosus patients. Six patients showed antibodies directed against nucleoporin p62. Our data indicate that p62 antibodies could be a useful additional marker in SLE.

Keywords: Systemic lupus erythematosus; autoantibodies; nucleoporin p62..