Clinical value of PET with 18F-fluorodeoxyglucose and L-methyl-11C-methionine for diagnosis of recurrent brain tumor and radiation injury

Acta Radiol. 1991 May;32(3):197-202.


We studied 15 patients clinically suspected to have recurrent brain tumor or radiation injury, using positron emission tomography (PET) with 18F-fluorodeoxyglucose (18FDG) and L-methyl-11C-methionine (11C-Met). PET with 11C-Met (Met-PET) clearly delineated the extent of recurrent brain tumor as focal areas of increased accumulation of 11C-Met, and was useful for early detection of recurrent brain tumor. PET with 18FDG (FDG-PET) showed focal 18FDG-hypermetabolism in one patient with malignant transformation of low grade glioma, and demonstrated its usefulness for evaluation of malignant transformation. 18FDG-hypometabolism was observed in all patients with radiation injury, but was also found in one patient with recurrent malignant brain tumor. 11C-Met uptake in 3 patients with radiation injury was similar to that of the normal cortical tissue. FDG-PET can be used to initially exclude recurrent brain tumor which is seen as 18FDG-hypermetabolism. The combined use of Met-PET in addition to FDG-PET can improve the accuracy of differentiation of recurrent brain tumor with 18FDG-hypometabolism from radiation injury.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Brain / diagnostic imaging
  • Brain / radiation effects
  • Brain Neoplasms / diagnostic imaging*
  • Brain Neoplasms / therapy
  • Child
  • Child, Preschool
  • Deoxyglucose / analogs & derivatives*
  • Female
  • Fluorodeoxyglucose F18
  • Humans
  • Male
  • Methionine / analogs & derivatives*
  • Middle Aged
  • Neoplasm Recurrence, Local / diagnostic imaging*
  • Radiation Injuries / diagnostic imaging*
  • Radiography
  • Radiotherapy / adverse effects
  • Tomography, Emission-Computed*
  • Vitamin U*


  • Fluorodeoxyglucose F18
  • Vitamin U
  • Deoxyglucose
  • Methionine
  • methionine methyl ester