Abstract
The 2-hydroxy and 4-hydroxyestradiols (2-/4-OHE2) caused marked cytotoxic effects, including vacuolation and nuclear changes, in rat epididymal epithelia, after exposure to very low levels (40 ng/rat/week) for 20 weeks. The effects of the 2-/4-OHE2 metabolites were more pronounced than that of estradiol-17 beta (E2).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cell Nucleus / drug effects
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Cell Nucleus / ultrastructure
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Dose-Response Relationship, Drug
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Epididymis / drug effects
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Epididymis / ultrastructure*
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Epithelium / drug effects
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Epithelium / ultrastructure
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Estradiol / administration & dosage
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Estradiol / analogs & derivatives*
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Estradiol / pharmacology
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Estrogens, Catechol
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Male
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Rats
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Rats, Inbred Strains
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Vacuoles / drug effects
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Vacuoles / ultrastructure
Substances
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Estrogens, Catechol
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Estradiol
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2-hydroxyestradiol
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4-hydroxyestradiol