Morphological effects of the catechol estrogens on rat epididymal epithelia

J Steroid Biochem Mol Biol. 1991 Jun;38(6):717-20. doi: 10.1016/0960-0760(91)90083-h.

Abstract

The 2-hydroxy and 4-hydroxyestradiols (2-/4-OHE2) caused marked cytotoxic effects, including vacuolation and nuclear changes, in rat epididymal epithelia, after exposure to very low levels (40 ng/rat/week) for 20 weeks. The effects of the 2-/4-OHE2 metabolites were more pronounced than that of estradiol-17 beta (E2).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Nucleus / drug effects
  • Cell Nucleus / ultrastructure
  • Dose-Response Relationship, Drug
  • Epididymis / drug effects
  • Epididymis / ultrastructure*
  • Epithelium / drug effects
  • Epithelium / ultrastructure
  • Estradiol / administration & dosage
  • Estradiol / analogs & derivatives*
  • Estradiol / pharmacology
  • Estrogens, Catechol
  • Male
  • Rats
  • Rats, Inbred Strains
  • Vacuoles / drug effects
  • Vacuoles / ultrastructure

Substances

  • Estrogens, Catechol
  • Estradiol
  • 2-hydroxyestradiol
  • 4-hydroxyestradiol