Interleukin-12 as an adjuvant for induction of protective antibody responses

Cytokine. Oct-Nov 2010;52(1-2):102-7. doi: 10.1016/j.cyto.2010.06.011. Epub 2010 Jul 22.

Abstract

Interleukin (IL)-12 is a pivotal cytokine that strongly stimulates Th1-associated cellular immunity. It is now recognized that IL-12 also activates humoral immunity to both T-dependent and T-independent antigens. This has let to considerable interest in exploiting IL-12 as a vaccine adjuvant for protection against various bacterial and viral pathogens, particularly in the lung. Studies examining the efficacy of IL-12-mediated effects on protective antibody response in the mouse model are summarized in this review.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Adjuvants, Immunologic / pharmacology*
  • Animals
  • Antibody Formation / drug effects*
  • Antibody Formation / immunology
  • Bacterial Infections / immunology
  • Bacterial Infections / prevention & control
  • Bacterial Vaccines / immunology
  • Bacterial Vaccines / pharmacology*
  • Humans
  • Immunity, Cellular / drug effects
  • Immunity, Cellular / immunology
  • Interleukin-12 / pharmacology*
  • Mice
  • Th1 Cells / immunology
  • Viral Vaccines / immunology
  • Viral Vaccines / pharmacology*
  • Virus Diseases / immunology
  • Virus Diseases / prevention & control

Substances

  • Adjuvants, Immunologic
  • Bacterial Vaccines
  • Viral Vaccines
  • Interleukin-12