Antipsychotic dosing: how much but also how often?

Schizophr Bull. 2010 Sep;36(5):900-3. doi: 10.1093/schbul/sbq083. Epub 2010 Jul 21.


Considerable focus has been devoted to how much antipsychotic is appropriate for optimal clinical response, although how often antipsychotics need to be administered is also less than clear. Clinicians are aware of the increased risk of relapse related to antipsychotic nonadherence/discontinuation, and current practice dictates continuous antipsychotic exposure with the goal of achieving steady state-levels to maintain effectiveness and prevent relapse. Does this mean we need to (or should) administer antipsychotics at least daily? There is a body of evidence challenging this long-established clinical axiom.

Publication types

  • Review

MeSH terms

  • Animals
  • Antipsychotic Agents / administration & dosage*
  • Antipsychotic Agents / adverse effects
  • Brain / drug effects
  • Delayed-Action Preparations
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Drug Tolerance
  • Dyskinesia, Drug-Induced / prevention & control
  • Humans
  • Long-Term Care
  • Rats
  • Receptors, Dopamine D2 / drug effects
  • Schizophrenia / drug therapy*
  • Schizophrenic Psychology*
  • Secondary Prevention


  • Antipsychotic Agents
  • Delayed-Action Preparations
  • Receptors, Dopamine D2