Amnesia following damage to the left fornix and to other sites. A comparative study

Brain. 1991 Jun;114 ( Pt 3):1297-313. doi: 10.1093/brain/114.3.1297.


Two memory-impaired patients, who had suffered damage to the left or both fornix columns during removal of a ventricular cyst, were compared with 3 others having left-sided hippocampal or thalamic lesions, and with normal controls. The tests used were nonverbal--scene recognition, delayed matching-to-sample and concurrent pattern and object discrimination learning. The last two are differentially sensitive to fornix transection and to hippocampal or thalamic ablations in monkeys; however, the patients with fornix damage did not show a distinctive pattern of impairment. The reasons for this discrepancy are discussed. The study adds to the evidence that fornix transection can cause wide-ranging memory disturbances in man.

Publication types

  • Case Reports
  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Amnesia / etiology*
  • Amnesia / psychology
  • Brain / diagnostic imaging
  • Brain / pathology*
  • Brain Damage, Chronic / etiology*
  • Brain Damage, Chronic / pathology
  • Brain Damage, Chronic / psychology
  • Brain Diseases / surgery*
  • Cysts / surgery*
  • Discrimination, Psychological
  • Female
  • Hippocampus / pathology*
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Memory
  • Middle Aged
  • Neuropsychological Tests
  • Organ Specificity
  • Postoperative Complications
  • Reference Values
  • Thalamus / pathology*
  • Tomography, X-Ray Computed