Content variations of the tomato saponin esculeoside A in various processed tomatoes

J Nat Med. 2011 Jan;65(1):176-9. doi: 10.1007/s11418-010-0443-4. Epub 2010 Jul 23.


A tomato saponin, esculeoside A, may be metabolized into various steroidal hormones such as pregnane derivatives that are expected to exhibit various bioactivities in the body, such as anti-osteoporosis, anti-menopausal disorder and anti-tumor actions. Therefore, we attempted to examine the esculeoside A contents of fresh tomatoes, tomatoes boiled in water, tomatoes heated using a microwave oven, freeze-dried tomatoes, and commercially available processed tomato products contained in plastic bottles and cans, in order to develop a health food.

MeSH terms

  • Food Handling
  • Freeze Drying
  • Hot Temperature
  • Microwaves
  • Sapogenins / chemistry*
  • Solanum lycopersicum / chemistry*


  • Sapogenins
  • esculeoside A