BioMOFs: metal-organic frameworks for biological and medical applications

Angew Chem Int Ed Engl. 2010 Aug 23;49(36):6260-6. doi: 10.1002/anie.201000048.


The class of highly porous materials called metal-organic frameworks offer many opportunities for applications across biology and medicine. Their wide range of chemical composition makes toxicologically acceptable formulation possible, and their high level of functionality enables possible applications as imaging agents and as delivery vehicles for therapeutic agents. The challenges in the area encompass not only the development of new solids but also improvements in the formulation and processing of the materials, including tailoring the morphology and surface chemistry of the frameworks to fit the proposed applications.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Contrast Media / chemistry
  • Drug Carriers / chemistry
  • Drug Carriers / toxicity
  • Metals / chemistry*
  • Nanoparticles / chemistry
  • Nanoparticles / ultrastructure
  • Organic Chemicals / chemistry*
  • Porosity


  • Contrast Media
  • Drug Carriers
  • Metals
  • Organic Chemicals