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. 2010 Jul 12;28(31):5057-67.
doi: 10.1016/j.vaccine.2010.05.006.

Design and Evaluation in Mice of a Broadly Protective Meningococcal Group B Native Outer Membrane Vesicle Vaccine

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Design and Evaluation in Mice of a Broadly Protective Meningococcal Group B Native Outer Membrane Vesicle Vaccine

Wendell D Zollinger et al. Vaccine. .

Abstract

A vaccine based on native outer membrane vesicles (NOMV) that has potential to provide safe, broad based protection against group B strains of Neisseria meningitidis has been developed. Three antigenically diverse group B strains of N. meningitidis were chosen and genetically modified to improve safety and expression of desirable antigens. Safety was enhanced by disabling three genes: synX, lpxL1, and lgtA. The vaccine strains were genetically configured to have three sets of antigens each with potential to induce protective antibodies against a wide range of group B strains. Preliminary immunogenicity studies with combined NOMV from the three strains confirmed the capacity of the vaccine to induce a broad based bactericidal antibody response. Analysis of the bactericidal activity indicated that antibodies to the LOS were responsible for a major portion of the bactericidal activity and that these antibodies may enhance the bactericidal activity of anti-protein antibodies.

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