Randomized controlled trial using vitamins E and D supplementation in atopic dermatitis

J Dermatolog Treat. 2011 Jun;22(3):144-50. doi: 10.3109/09546630903578566. Epub 2010 Jul 24.


Background: Atopic dermatitis is a chronically relapsing, highly pruritic and inflammatory skin disease. This study was done to assess the effects of vitamins D and E supplementation on the clinical manifestation of atopic dermatitis.

Methods: Forty-five atopic dermatitis patients were included in a randomized, double-blind, placebo-controlled trial. They were randomly divided into four groups and treated for 60 days: group P (n = 11), vitamins D and E placebos; group D (n = 12), 1600 IU vitamin D(3) plus vitamin E placebo; group E (n = 11), 600 IU synthetic all-rac-α-tocopherol plus vitamin D placebo; and group DE (n = 11), 1600 IU vitamin D(3) plus 600 IU synthetic all-rac-α-tocopherol. Serum 25(OH) vitamin D and plasma α-tocopherol were determined before and after the trial. The clinical improvement was evaluated with SCORing Atopic Dermatitis (SCORAD). Data were analyzed by analysis of variance (ANOVA) and Kruskal-Wallis tests.

Results: SCORAD was reduced after 60 days in groups D, E and DE by 34.8%, 35.7% and 64.3%, respectively (p = 0.004). Objective SCORAD also showed significant improvement. There was a positive correlation between SCORAD and intensity, objective, subjective and extent (p < 0.001). We found a significant negative association between plasma α-tocopherol and SCORAD, intensity, objective and extent (p = 0.02).

Conclusion: This study supports the contributing and beneficial effects of vitamins D and E in the treatment of atopic dermatitis.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Dermatitis, Atopic / drug therapy*
  • Dermatitis, Atopic / pathology
  • Dietary Supplements
  • Double-Blind Method
  • Female
  • Humans
  • Male
  • Vitamin D / analogs & derivatives
  • Vitamin D / blood
  • Vitamin D / therapeutic use*
  • Vitamin E / therapeutic use*
  • alpha-Tocopherol / blood


  • Vitamin D
  • Vitamin E
  • 25-hydroxyvitamin D
  • alpha-Tocopherol