Multifunctional agents for concurrent imaging and therapy in cardiovascular disease

Adv Drug Deliv Rev. 2010 Aug 30;62(11):1023-30. doi: 10.1016/j.addr.2010.07.004. Epub 2010 Jul 21.

Abstract

The development of agents for the simultaneous detection and treatment of disease has recently gained significant attention. These multifunctional theranostic agents posses a number of advantages over their monofunctional counterparts, as they potentially allow for the concomitant determination of agent localization, release, and efficacy. Whereas the development of these agents for use in cancers has received the majority of the attention, their use in cardiovascular disease is steadily increasing. As such, this review summarized some of the most poignant recent advances in the development of theranostic agents for the treatment of this class of diseases.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Cardiovascular Diseases / diagnosis*
  • Cardiovascular Diseases / drug therapy*
  • Diagnostic Imaging / methods*
  • Drug Carriers / therapeutic use*
  • Drug Delivery Systems / methods
  • Humans
  • Nanoparticles / therapeutic use

Substances

  • Drug Carriers