The MRN complex in double-strand break repair and telomere maintenance

FEBS Lett. 2010 Sep 10;584(17):3682-95. doi: 10.1016/j.febslet.2010.07.029. Epub 2010 Jul 24.


Genomes are subject to constant threat by damaging agents that generate DNA double-strand breaks (DSBs). The ends of linear chromosomes need to be protected from DNA damage recognition and end-joining, and this is achieved through protein-DNA complexes known as telomeres. The Mre11-Rad50-Nbs1 (MRN) complex plays important roles in detection and signaling of DSBs, as well as the repair pathways of homologous recombination (HR) and non-homologous end-joining (NHEJ). In addition, MRN associates with telomeres and contributes to their maintenance. Here, we provide an overview of MRN functions at DSBs, and examine its roles in telomere maintenance and dysfunction.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • DNA Breaks, Double-Stranded
  • DNA Damage / genetics*
  • DNA Repair / genetics*
  • Genome
  • Humans
  • Mice
  • Models, Animal
  • Mutation
  • Nijmegen Breakage Syndrome / genetics
  • Sequence Deletion / genetics
  • Signal Transduction
  • Telomere / genetics*