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doi: 10.1016/j.cell.2010.07.006.
Giving Alzheimer's the old one-two
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- PMID: 20655461
- DOI: 10.1016/j.cell.2010.07.006
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Giving Alzheimer's the old one-two
Cell.
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Free article
Abstract
A dual goal for treating Alzheimer's disease (AD) is to decrease deposition of neurotoxic amyloid beta-peptide in the brain and to boost repair of damaged neurons. Donmez et al. (2010) now show that SIRT1 may mediate both processes by deacetylating the transcription factor retinoic acid receptor beta, a potential new therapeutic target for AD.
Copyright 2010 Elsevier Inc. All rights reserved.
Comment on
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SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10.Cell. 2010 Jul 23;142(2):320-32. doi: 10.1016/j.cell.2010.06.020. Cell. 2010. Retraction in: Cell. 2014 Aug 14;158(4):959. doi: 10.1016/j.cell.2014.06.035 PMID: 20655472 Free PMC article. Retracted.
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