Antiobesity and lipid lowering effects of Murraya koenigii (L.) Spreng leaves extracts and mahanimbine on high fat diet induced obese rats

Fitoterapia. 2010 Dec;81(8):1129-33. doi: 10.1016/j.fitote.2010.07.013. Epub 2010 Jul 23.

Abstract

The dichloromethane (MKD) and ethyl acetate (MKE) extracts of Murraya koenigii leaves significantly reduced the body weight gain, plasma total cholesterol (TC) and triglyceride (TG) levels significantly when given orally at a dose of 300 mg/kg/day to the high fat diet (HFD) induced obese rats for 2 weeks. The observed antiobesity and antihyperlipidemic activities of these extract are correlated with the carbazole alkaloids present in them. Mahanimbine (1) when given orally (30 mg/kg/day) also significantly lowered the body weight gain as well as plasma TC and TG levels. These findings demonstrate the excellent pharmacological potential of mahanimbine to prevent obesity.

MeSH terms

  • Animals
  • Anti-Obesity Agents / chemistry
  • Anti-Obesity Agents / pharmacology
  • Carbazoles / chemistry
  • Carbazoles / pharmacology*
  • Dietary Fats / adverse effects*
  • Heterocyclic Compounds, 4 or More Rings / chemistry
  • Heterocyclic Compounds, 4 or More Rings / pharmacology*
  • Hypolipidemic Agents / chemistry
  • Hypolipidemic Agents / pharmacology
  • Male
  • Molecular Structure
  • Murraya / chemistry*
  • Obesity / chemically induced
  • Obesity / drug therapy*
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology*
  • Plant Leaves / chemistry*
  • Rats
  • Rats, Sprague-Dawley

Substances

  • Anti-Obesity Agents
  • Carbazoles
  • Dietary Fats
  • Heterocyclic Compounds, 4 or More Rings
  • Hypolipidemic Agents
  • Plant Extracts
  • mahanimbine