Signaling by members of the TGF-beta family in vascular morphogenesis and disease

Trends Cell Biol. 2010 Sep;20(9):556-67. doi: 10.1016/j.tcb.2010.06.006. Epub 2010 Jul 23.


Members of the transforming growth factor-beta (TGF-beta) family play pivotal roles in development and disease. These cytokines elicit their pleiotropic effects on cells, including endothelial and mural cells, through specific type I and type II serine/threonine kinase receptors and intracellular Smad transcription factors. This review highlights recent progress in our understanding of TGF-beta signaling in vascular development and angiogenesis and of how perturbed TGF-beta signaling might contribute to vascular pathologies, tumor angiogenesis and tumor progression. Recent research has provided exciting insights into the role of the TGF-beta type I receptor (ALK1) in tumor angiogenesis and the curative effects of thalidomide on vascular malformations in hereditary hemorrhagic telangiectasia (HHT). These advances provide opportunities for the development of new therapies for diseases with vascular abnormalities.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Blood Vessels / embryology
  • Humans
  • Morphogenesis
  • Neovascularization, Pathologic*
  • Neovascularization, Physiologic*
  • Signal Transduction*
  • Transforming Growth Factor beta / metabolism*


  • Transforming Growth Factor beta