Convenient and efficient microwave-assisted synthesis of a methyl derivative of the fused indoloquinoline alkaloid cryptosanguinolentine

Molecules. 2010 Apr 29;15(5):3171-8. doi: 10.3390/molecules15053171.


An efficient synthesis of a methyl derivative of the indoloquinoline alkaloid cryptosanguinolentine based on microwave-assisted reactions is described. The microwave-assisted synthesis of an intermediate 4-hydroxy-2-methylquinoline yielded 86% of the desired product and other intermediates prepared yielded high % of products in shorter reaction times, under optimum conditions, as compared to traditional methods.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / chemical synthesis
  • Hydroxyquinolines / chemical synthesis*
  • Indole Alkaloids / chemical synthesis*
  • Indolequinones / chemical synthesis
  • Methylation
  • Microwaves
  • Quinaldines / chemical synthesis*


  • Alkaloids
  • Hydroxyquinolines
  • Indole Alkaloids
  • Indolequinones
  • Quinaldines
  • cryptosanguinolentine
  • 2-methylquinoline