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. 2010 Apr 30;15(5):3200-10.
doi: 10.3390/molecules15053200.

Activities of Ten Essential Oils Towards Propionibacterium Acnes and PC-3, A-549 and MCF-7 Cancer Cells

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Free PMC article

Activities of Ten Essential Oils Towards Propionibacterium Acnes and PC-3, A-549 and MCF-7 Cancer Cells

Yuangang Zu et al. Molecules. .
Free PMC article

Abstract

Ten essential oils, namely, mint (Mentha spicata L., Lamiaceae), ginger (Zingiber officinale Rosc., Zingiberaceae), lemon (Citrus limon Burm.f., Rutaceae), grapefruit (Citrus paradisi Macf., Rutaceae), jasmine (Jasminum grandiflora L., Oleaceae), lavender (Mill., Lamiaceae), chamomile (Matricaria chamomilla L., Compositae), thyme (Thymus vulgaris L., Lamiaceae), rose (Rosa damascena Mill., Rosaceae) and cinnamon (Cinnamomum zeylanicum N. Lauraceae) were tested for their antibacterial activities towards Propionibacterium acnes and in vitro toxicology against three human cancer cell lines. Thyme, cinnamon and rose essential oils exhibited the best antibacterial activities towards P. acnes, with inhibition diameters of 40 +/- 1.2 mm, 33.5 +/- 1.5 mm and 16.5 +/- 0.7 mm, and minimal inhibitory concentrations of 0.016% (v/v), 0.016% (v/v) and 0.031% (v/v), respectively. Time-kill dynamic procedures showed that thyme, cinnamon, rose, and lavender essential oils exhibited the strongest bactericidal activities at a concentration of 0.25% (v/v), and P. acnes was completely killed after 5 min. The thyme essential oil exhibited the strongest cytotoxicity towards three human cancer cells. Its inhibition concentration 50% (IC(50)) values on PC-3, A549 and MCF-7 tumor cell lines were 0.010% (v/v), 0.011% (v/v) and 0.030% (v/v), respectively. The cytotoxicity of 10 essential oils on human prostate carcinoma cell (PC-3) was significantly stronger than on human lung carcinoma (A549) and human breast cancer (MCF-7) cell lines.

Figures

Figure 1
Figure 1
Inhibition diameters of 10 essential oils towards P. acnes.
Figure 2
Figure 2
Time-kill curves of 10 essential oils (0.25% v/v) towards P.acnes in 2h. (A): essential oils of mint, ginger, rose, cinnamon, and grapefruit; (B): essential oils of jasmine, lavender, chamomile, thyme, and lemon.
Figure 3
Figure 3
Dose-dependent cytotoxicity of 10 essential oils (72 h exposure) towards PC-3 (A), A549 (B) and MCF-7 (C) cell lines as determined by the MTT assay. Values are expressed as means ± SD of three independent experiments. Standard deviations were less than 15%.

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References

    1. Buckle J. Use of aromatherapy as a complementary treatment for chronic pain. Altern Ther Health Med. 1999;5:42–51. - PubMed
    1. Sylvestre M., Pichette A., Longtin A., Nagau F., Legault J. Essential oil analysis and anticancer activity of leaf essential oil of Croton flavens L. from Guadeloupe. J. Ethnopharmacol. 2006;103:99–102. doi: 10.1016/j.jep.2005.07.011. - DOI - PubMed
    1. Mimica-Dukic N., Bozin B., Sokovic M., Simin N. Antimicrobial and antioxidant activities of Melissa officinalis L. (Lamiaceae) essential oil. J. Agric. Food. Chem. 2004;52:2485–2489. doi: 10.1021/jf030698a. - DOI - PubMed
    1. Sylvestre M., Legault J., Dufour D., Pichette A. Chemical composition and anticancer activity of leaf essential oil of Myrica gale L. Phytomedicine. 2005;12:299–304. doi: 10.1016/j.phymed.2003.12.004. - DOI - PubMed
    1. Park J., Lee J., Jung E., Park Y., Kim K., Park B., Jung K., Park E., Kim J., Park D. In vitro antibacterial and anti-inflammatory effects of honokiol and magnolol against Propionibacterium sp. Eur. J. Pharmacol. 2004;496:189–195. doi: 10.1016/j.ejphar.2004.05.047. - DOI - PubMed

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