Prevalence of daily medication adherence among children with sickle cell disease: a 1-year retrospective cohort analysis

Pediatr Blood Cancer. 2010 Sep;55(3):554-6. doi: 10.1002/pbc.22605.


The objective of this study is to determine the prevalence of adherence to daily medications among children with sickle cell disease (SCD). Prescription records for 12 months were obtained from participants who had insurance in a Medicaid-based single health maintenance organization. Adherence was measured as a ratio between the number of expected days and the observed days between two refill periods for daily medications. A total of 93 children were studied. The average refill prescription rate was 58.4%. More formal strategies are required to identify barriers to prescription refills among children with SCD.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anemia, Sickle Cell / complications
  • Anemia, Sickle Cell / drug therapy*
  • Anti-Asthmatic Agents / therapeutic use
  • Antisickling Agents / therapeutic use
  • Child
  • Cohort Studies
  • Folic Acid / therapeutic use
  • Hematinics / therapeutic use
  • Humans
  • Hydroxyurea / therapeutic use
  • Medication Adherence*
  • Penicillins / therapeutic use


  • Anti-Asthmatic Agents
  • Antisickling Agents
  • Hematinics
  • Penicillins
  • Folic Acid
  • Hydroxyurea