Abstract
The Sas10/C1D domain is found in a small group of eukaryotic proteins that have functions in RNA processing events, translational control and DNA repair mechanisms. The domain is predicted to be alpha-helical in nature and comprises approx. 80 amino acid residues. Whereas the Sas10/C1D domain has yet to be functionally characterized, available results suggest that this domain forms a binding surface for specific interactions with other proteins and can concomitantly interact with RNA or DNA. This property of the Sas10/C1D domain may facilitate this family of proteins to dock other proteins on to nucleic acid substrates.
Publication types
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Amino Acid Sequence
-
Animals
-
DNA / metabolism
-
DNA-Binding Proteins / chemistry*
-
DNA-Binding Proteins / metabolism
-
DNA-Binding Proteins / physiology*
-
Exosome Multienzyme Ribonuclease Complex
-
Humans
-
Models, Biological
-
Molecular Sequence Data
-
Nuclear Proteins / chemistry*
-
Nuclear Proteins / metabolism
-
Nuclear Proteins / physiology*
-
Protein Binding / physiology
-
Protein Interaction Domains and Motifs / physiology
-
RNA / metabolism
-
RNA-Binding Proteins / chemistry*
-
RNA-Binding Proteins / metabolism
-
RNA-Binding Proteins / physiology*
-
Saccharomyces cerevisiae / genetics
-
Saccharomyces cerevisiae / physiology
-
Saccharomyces cerevisiae Proteins / chemistry*
-
Saccharomyces cerevisiae Proteins / metabolism
-
Saccharomyces cerevisiae Proteins / physiology*
-
Sequence Homology, Amino Acid
Substances
-
DNA-Binding Proteins
-
LRP1 protein, S cerevisiae
-
Nuclear Proteins
-
RNA-Binding Proteins
-
Saccharomyces cerevisiae Proteins
-
Sas10 protein, S cerevisiae
-
RNA
-
DNA
-
Exosome Multienzyme Ribonuclease Complex