The pathophysiological mechanism underlying Brugada syndrome: depolarization versus repolarization

J Mol Cell Cardiol. 2010 Oct;49(4):543-53. doi: 10.1016/j.yjmcc.2010.07.012. Epub 2010 Jul 24.


This Point/Counterpoint presents a scholarly debate of the mechanisms underlying the electrocardiographic and arrhythmic manifestations of Brugada syndrome (BrS), exploring in detail the available evidence in support of the repolarization vs. depolarization hypothesis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Arrhythmias, Cardiac / physiopathology
  • Brugada Syndrome / physiopathology*
  • Cardiac Electrophysiology / methods
  • Electrocardiography
  • Humans