Sequence of pNL194, a 79.3-kilobase IncN plasmid carrying the blaVIM-1 metallo-beta-lactamase gene in Klebsiella pneumoniae

Antimicrob Agents Chemother. 2010 Oct;54(10):4497-502. doi: 10.1128/AAC.00665-10. Epub 2010 Jul 26.

Abstract

The nucleotide sequence of pNL194, a VIM-1-encoding plasmid, is described in this study. pNL194 (79,307 bp) comprised an IncN-characteristic segment (38,940 bp) and a mosaic structure (40,367 bp) including bla(VIM-1), aacA7, aadA1, aadA2, dfrA1, dfrA12, aphA1, strA, strB, and sul1. Tn1000 or Tn5501 insertion within fipA probably facilitated recruitment of additional mobile elements carrying resistance genes.

MeSH terms

  • Bacterial Proteins / genetics*
  • Klebsiella pneumoniae / genetics*
  • Models, Genetic
  • Molecular Sequence Data
  • Plasmids / genetics*
  • beta-Lactamases / genetics*

Substances

  • Bacterial Proteins
  • beta-Lactamases

Associated data

  • GENBANK/GU585907