Intraocular tuberculosis

Ocul Immunol Inflamm. 2010 Aug;18(4):281-91. doi: 10.3109/09273948.2010.489729.

Abstract

Intraocular manifestations of tuberculosis (TB) are rare, but TB infection is common worldwide, especially in developing economies, and in immigrant populations and immunocompromised patients in developed nations. The current review focuses on the clinical characteristics and diagnostic modalities useful in the diagnosis of intraocular TB. Specifically, IFN-gamma Release Assays (IGRAs), antigen-detection assays, and polymerase chain reactions will be discussed. Clinical management of TB patients includes counseling and testing for HIV infection. The use of corticosteroids along with anti-tuberculous medications and special therapeutic considerations in immunocompromised patients are discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adrenal Cortex Hormones / therapeutic use
  • Antigens, Bacterial / analysis
  • Antigens, Bacterial / immunology
  • Antitubercular Agents / therapeutic use*
  • HIV Infections / diagnosis
  • HIV Infections / immunology
  • HIV Infections / microbiology
  • Humans
  • Immunocompromised Host / drug effects*
  • Immunocompromised Host / immunology
  • Interferon-gamma / analysis
  • Male
  • Mycobacterium tuberculosis / drug effects*
  • Mycobacterium tuberculosis / immunology
  • Mycobacterium tuberculosis / isolation & purification
  • Polymerase Chain Reaction
  • Tuberculosis, Ocular / diagnosis*
  • Tuberculosis, Ocular / drug therapy*
  • Tuberculosis, Ocular / epidemiology
  • Tuberculosis, Ocular / microbiology

Substances

  • Adrenal Cortex Hormones
  • Antigens, Bacterial
  • Antitubercular Agents
  • Mycobacterium tuberculosis antigens
  • Interferon-gamma