Wound inflammatory index: a "proof of concept" study to assess wound healing trajectory

J Diabetes Sci Technol. 2010 Jul 1;4(4):773-9. doi: 10.1177/193229681000400402.

Abstract

Diabetes around the globe results in one major limb amputation every 30 seconds, over 2500 limbs lost per day. The underlying pathophysiology sometimes leads to a chronic inflammatory stage, which may prevent appropriate healing, and therefore, the need for a clear strategy for assessing and classifying wounds and wound healing cannot be overstated. Temperature is a surrogate marker for inflammation. Quantitative thermography using a numerical index provides a useful way to assess wound healing. Advances in technology have afforded the availability of low-cost, high-resolution thermal imaging systems, which can be used to quantify sensitive changes on the skin surface and may be particularly useful to develop monitoring strategies for wounds. This article provides a standardized technique for calculating a thermal index (TI) supported with a case report from assessment of a diabetic foot ulcer. In this single case study, the TI/wound inflammatory index indicates a shift from negative to positive (p < .05) before it reaches zero.

Publication types

  • Case Reports
  • Research Support, N.I.H., Extramural

MeSH terms

  • Algorithms
  • Amputation / adverse effects
  • Diabetic Foot / pathology*
  • Diagnostic Imaging
  • Humans
  • Inflammation / pathology*
  • Male
  • Middle Aged
  • Skin Temperature / physiology
  • Thermography
  • Wound Healing / physiology*
  • Wounds and Injuries / pathology*