BK channel activation: structural and functional insights

Trends Neurosci. 2010 Sep;33(9):415-23. doi: 10.1016/j.tins.2010.06.004.


The voltage- and Ca(2+)-activated K(+) (BK) channels are involved in the regulation of neurotransmitter release and neuronal excitability. Structurally, BK channels are homologous to voltage- and ligand-gated K(+) channels, having a voltage sensor and pore as the membrane-spanning domain and a cytosolic domain containing metal binding sites. Recently published electron cryomicroscopy (cryo-EM) and X-ray crystallographic structures of the BK channel provided the first glimpse into the assembly of these domains, corroborating the close interactions among these domains during channel gating that have been suggested by functional studies. This review discusses these latest findings and an emerging new understanding about BK channel gating and implications for diseases such as epilepsy, in which mutations in BK channel genes have been associated.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Calcium / metabolism
  • Channelopathies / genetics
  • Channelopathies / physiopathology
  • Crystallography, X-Ray
  • Epilepsy / genetics
  • Epilepsy / physiopathology
  • Ion Channel Gating / physiology*
  • Large-Conductance Calcium-Activated Potassium Channels / chemistry*
  • Large-Conductance Calcium-Activated Potassium Channels / genetics
  • Large-Conductance Calcium-Activated Potassium Channels / metabolism*
  • Magnesium / metabolism
  • Models, Molecular
  • Protein Conformation*


  • Large-Conductance Calcium-Activated Potassium Channels
  • Magnesium
  • Calcium