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Review
. 2011 Jan;27(1):31-9.
doi: 10.1016/j.pt.2010.06.016. Epub 2010 Jul 19.

A Genotype and Phenotype Database of Genetically Modified Malaria-Parasites

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Review

A Genotype and Phenotype Database of Genetically Modified Malaria-Parasites

Chris J Janse et al. Trends Parasitol. .

Abstract

The RMgm database, www.pberghei.eu, is a web-based, manually curated, repository containing information on genetically modified rodent-malaria parasites. It provides easy and rapid access to information on the genotype and phenotype of mutant and reporter parasites. The database also contains information on unpublished mutants without a clear phenotype and negative trials to disrupt genes. Information can be searched using pre-defined key features, such as phenotype, life-cycle stage, gene model, gene-tags and mutations. The information relating to the mutants is reciprocally linked to PlasmoDB and GeneDB. Access to mutant-parasite information, and gene function/ontology inferred from mutant phenotypes provides a timely resource aimed at enhancing research into Plasmodium gene function and (systems) biology.

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