Coelomycin, a Highly Substituted 2,6-dioxo-pyrazine Fungal Metabolite Antibacterial Agent Discovered by Staphylococcus Aureus Fitness Test Profiling

J Antibiot (Tokyo). 2010 Aug;63(8):512-8. doi: 10.1038/ja.2010.86. Epub 2010 Jul 28.

Abstract

Bacterial resistance to antibiotics, particularly to multiple antibiotics, is becoming a cause for significant concern. The only really viable course of action to counter this is to discover new antibiotics with novel modes of action. We have recently implemented a new antisense-based chemical genetic screening technology to accomplish this goal. The discovery and antibacterial activity of coelomycin, a fully substituted 2,6-dioxo pyrazine, illustrates the application of the Staphylococcus aureus fitness test strategy to natural products discovery.

MeSH terms

  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / isolation & purification*
  • Anti-Bacterial Agents / pharmacology*
  • Ascomycota / isolation & purification
  • Ascomycota / metabolism*
  • Drug Evaluation, Preclinical / methods
  • Humans
  • Juniperus / microbiology
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Pyrazines / chemistry
  • Pyrazines / isolation & purification*
  • Pyrazines / pharmacology*
  • Staphylococcus aureus / drug effects*
  • Staphylococcus aureus / physiology*

Substances

  • Anti-Bacterial Agents
  • Pyrazines