A 15-year-old young man was referred for evaluation of a non-tender swelling of the left mandibular angle region. A non-ossifying fibroma was diagnosed. The lesion was enucleated under general anesthesia. The postoperative course was uneventful. There have been no signs of recurrence, and there was complete bone regeneration in the region 24 months after operation. This report also reviews other fifteen cases of non-ossifying fibroma in the mandible reported in the literature.