Abstract
13 α,21-Dihydroeurycomanone (1), a known quassinoid of Eurycoma longifolia Jack was recrystallized from chloroform into a novel crystal structure in space group P2 (1). Its X-ray data were compared with those of eurycomanone ( 2). Following intraperioneal injections at similar doses of 2.44 µmol/kg/day for 3 consecutive days, 2 displayed comparable potency with tamoxifen but was more potent than 1 in the anti-estrogenic effect against 17 α-ethynylestradiol (EE)-induced uterotrophy of immature rats.
© Georg Thieme Verlag KG Stuttgart · New York.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Crystallography, X-Ray
-
Estrogen Antagonists / chemistry*
-
Estrogen Antagonists / isolation & purification
-
Estrogen Antagonists / pharmacology*
-
Estrogen Antagonists / therapeutic use
-
Ethinyl Estradiol / pharmacology
-
Eurycoma / chemistry*
-
Female
-
Molecular Conformation
-
Plant Extracts / chemistry
-
Plant Extracts / isolation & purification
-
Plant Extracts / pharmacology
-
Plant Extracts / therapeutic use
-
Plant Roots / chemistry
-
Plants, Medicinal / chemistry
-
Quassins / chemistry*
-
Quassins / isolation & purification
-
Quassins / pharmacology*
-
Quassins / therapeutic use
-
Rats
-
Tamoxifen / pharmacology
-
Tamoxifen / therapeutic use
-
Uterus / drug effects
Substances
-
Estrogen Antagonists
-
Plant Extracts
-
Quassins
-
eurycomanone
-
Tamoxifen
-
Ethinyl Estradiol