Histological determination of the areas enriched in cholinergic terminals and M2 and M3 muscarinic receptors in the mouse central auditory system

Anat Rec (Hoboken). 2010 Aug;293(8):1393-9. doi: 10.1002/ar.21186.

Abstract

Cholinergic projections to auditory system are vital for coupling arousal with sound processing. Systematic search with in situ hybridization and immunohistochemistry indicated that the ventral nucleus of the medial geniculate body and the nucleus of the brachium of the inferior colliculus constituted cholinergic synaptic sites in the brainstem auditory system, containing a significant number of cholinergic axon terminals and m2 receptor-expressing cell bodies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Auditory Cortex / chemistry
  • Auditory Cortex / cytology*
  • Auditory Pathways
  • Brain Stem / cytology*
  • Brain Stem / metabolism
  • Cholinergic Fibers / chemistry
  • Cholinergic Fibers / ultrastructure*
  • Cochlear Nucleus / chemistry
  • Cochlear Nucleus / cytology
  • Geniculate Bodies / chemistry
  • Geniculate Bodies / cytology*
  • Immunohistochemistry
  • In Situ Hybridization
  • Inferior Colliculi / chemistry
  • Inferior Colliculi / cytology*
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Presynaptic Terminals / chemistry
  • Presynaptic Terminals / ultrastructure
  • Receptor, Muscarinic M2 / analysis*
  • Receptor, Muscarinic M3 / analysis*
  • Vesicular Acetylcholine Transport Proteins / analysis

Substances

  • Receptor, Muscarinic M2
  • Receptor, Muscarinic M3
  • Vesicular Acetylcholine Transport Proteins