Cryptococcal panniculitis in an immunocompromised patient: a case report and review of the literature

Cutis. 2010 Jun;85(6):303-6.


Cryptococcus neoformans is a dimorphic fungus known to cause disease predominately in immuno-compromised patients. It is not uncommon for cryptococcal disease to manifest within the cutaneous tissues of these patients, and it can have drastically varied presentations, from ulcerated nodules to a more subtle cellulitis. We present a patient who underwent a cardiac transplant and developed a fever and mildly erythematous, indurated plaques on his legs and flank several years later. Skin biopsy revealed cryptococcal panniculitis and C neoformans subsequently grew from both the biopsy culture and the cerebrospinal fluid (CSF). This case report highlights the varied and subtle presentations of cutaneous cryptococcosis in immunocompromised patients and encourages a high index of suspicion for this potentially fatal disease in the setting of immunosuppression.

Publication types

  • Case Reports

MeSH terms

  • Cryptococcosis / diagnosis
  • Cryptococcosis / etiology*
  • Cryptococcus neoformans / isolation & purification
  • Dermatomycoses / diagnosis
  • Dermatomycoses / etiology
  • Heart Transplantation
  • Humans
  • Immunocompromised Host*
  • Immunosuppressive Agents / therapeutic use
  • Male
  • Middle Aged
  • Panniculitis / diagnosis
  • Panniculitis / etiology*


  • Immunosuppressive Agents