Primary and bilateral tubal carcinoma is associated with long-standing granulomatous inflammation and primary infertility: a case report

J Obstet Gynaecol Res. 2010 Aug;36(4):912-5. doi: 10.1111/j.1447-0756.2010.01211.x.


We report a case of bilateral and primary tubal carcinoma associated with granulomatous inflammation and long-standing primary infertility. A 38-year-old woman with a 17-year history of primary infertility presented with lower abdominal pain and granulomatous inflammation in the endometrial biopsy. Bilateral adnexal masses measuring 4 and 6 cm in size were detected and the serum cancer antigen 125 level was 141 IU/ml. Laparoscopic surgical exploration and frozen section on the resected tubes revealed bilateral fallopian tube adenocarcinoma and then a staging laparotomy was performed. Histopathological examination showed a primary bilateral Grade 2 tubal serous adenocarcinoma of Stage 1b associated with granulomatous salpingitis. Primary fallopian tube carcinomas in young women are extremely rare gynecological tumors that are infrequently diagnosed prior to surgical exploration and their cause is unknown. A definitive diagnosis could be made on the histopathological examination in our case with the evidence of chronic pelvic inflammation. Our findings suggest that chronic pelvic inflammation may play a role in carcinogenesis in the tubes of infertile women.

Publication types

  • Case Reports

MeSH terms

  • Adenocarcinoma / complications*
  • Adenocarcinoma / pathology
  • Adult
  • Fallopian Tube Neoplasms / complications*
  • Fallopian Tube Neoplasms / pathology
  • Female
  • Humans
  • Infertility, Female / complications*
  • Infertility, Female / pathology
  • Inflammation / complications
  • Inflammation / pathology