The relationship of airway hyperresponsiveness and airway inflammation: Airway hyperresponsiveness in asthma: its measurement and clinical significance

Chest. 2010 Aug;138(2 Suppl):4S-10S. doi: 10.1378/chest.10-0100.


Airway hyperresponsiveness (AHR) is a clinical feature of asthma and is often in proportion to the underlying severity of the disease. To understand AHR and the mechanisms that contribute to these processes, it is helpful to divide the airway components that affect this feature of asthma into "persistent" and "variable" categories. The persistent component of AHR represents structural changes in the airway, whereas the variable feature relates to inflammatory events. Insight into how these interrelated components of AHR can contribute to asthma is gained by studying treatment effects and models of asthma provocation.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Airway Resistance / physiology*
  • Animals
  • Asthma / diagnosis
  • Asthma / physiopathology*
  • Breath Tests / methods*
  • Bronchial Hyperreactivity / diagnosis*
  • Bronchial Hyperreactivity / physiopathology
  • Bronchoconstriction / physiology*
  • Humans