This study examined the setting/House-level characteristics of 160 self-governed, mutual-support substance abuse recovery homes (OHs) across the U.S. These dwellings were located in four different neighborhood types: upper/middle class (n = 23 Houses), urban working/lower class (n = 71 Houses), suburban upper/middle-class (n = 39 Houses), and suburban working/lower class (n = 27 Houses). Interior dwelling characteristics and amenities located within a 2-block radius were similar across the four neighborhood types. However, Houses in urban, working, and lower class neighborhoods reported more alcohol/drug intoxicated persons. Most importantly, despite the greater potential for environmental temptations and easier access for substances, none of the neighborhood factors including neighborhood socio-economic status significantly predicted relapse rates over a 12 month period.