Abstract
In this study, we investigated the anticancer properties of methoxy-substituted nickel(II)(salophene) derivatives. We demonstrated that the most active complex [NiII(3-OMe-salophene)] is not necrotic in Burkitt-like lymphoma cells (BJAB) and human B-cell precursor cells (Nalm-6). [NiII(3-OMe-salophene)] inhibited proliferation and induced apoptosis in a concentration dependent manner, giving evidence for the involvement of CD95 receptor-mediated, extrinsic pathway. Furthermore, [NiII(3-OMe-salophene)] overcame vincristine drug resistance in BJAB and Nalm-6 cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology
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Apoptosis / drug effects
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Apoptosis Regulatory Proteins
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Coordination Complexes / chemical synthesis*
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Coordination Complexes / chemistry
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Coordination Complexes / pharmacology
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Drug Resistance, Neoplasm / drug effects
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Drug Screening Assays, Antitumor
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Fas-Associated Death Domain Protein / biosynthesis
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Humans
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Intracellular Signaling Peptides and Proteins
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Magnetic Resonance Spectroscopy
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Mitochondrial Proteins / biosynthesis
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Necrosis
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Signal Transduction
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Structure-Activity Relationship
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Vincristine / pharmacology
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fas Receptor / physiology
Substances
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Antineoplastic Agents
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Apoptosis Regulatory Proteins
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Coordination Complexes
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DIABLO protein, human
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Fas-Associated Death Domain Protein
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Intracellular Signaling Peptides and Proteins
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Mitochondrial Proteins
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fas Receptor
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Vincristine