The other Janus face of Qa-1 and HLA-E: diverse peptide repertoires in times of stress

Microbes Infect. 2010 Nov;12(12-13):910-8. doi: 10.1016/j.micinf.2010.07.011. Epub 2010 Jul 27.


The non-polymorphic MHC molecule Qa-1 and its human counterpart HLA-E present monomorphic signal peptides to innate receptors and thereby regulate lymphocyte activity. Under stress, this peptide content is replaced with a surprisingly diverse repertoire of novel peptides that are associated with heat-shock proteins, infectious agents or antigen processing defects.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigen Presentation*
  • HLA Antigens / immunology*
  • Histocompatibility Antigens Class I / immunology*
  • Humans
  • Immunity, Cellular*
  • Mice
  • Signal Transduction


  • HLA Antigens
  • HLA-E antigen
  • Histocompatibility Antigens Class I
  • Q surface antigens