The role of capsaicin-sensitive afferent nerves in protective effect of capsaicin against absolute ethanol-induced gastric lesions in rats

Jpn J Pharmacol. 1991 Feb;55(2):279-82. doi: 10.1254/jjp.55.279.


The role of capsaicin-sensitive afferent nerves in gastroprotection by capsaicin was investigated in the absolute ethanol-induced gastric lesion model in rats. Capsaicin (0.1 and 0.5 mg/kg, p.o.) inhibited the lesion formation dose-dependently. The protective effect of capsaicin was attenuated by indomethacin-pretreatment and disappeared in capsaicin-sensitive nerve degenerated rats. Capsaicin did not induce the distension of gastric mucosal folds. These results suggested that stimulation of capsaicin-sensitive afferent nerves by capsaicin would enhance the prostaglandin formation, leading to an inhibition of gastric lesions.

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology
  • Capsaicin / pharmacology*
  • Disease Models, Animal
  • Ethanol
  • Gastric Mucosa / drug effects
  • Gastric Mucosa / innervation*
  • Indomethacin / pharmacology
  • Male
  • Neurons, Afferent / drug effects*
  • Rats
  • Rats, Inbred Strains
  • Stomach Diseases / chemically induced
  • Stomach Diseases / prevention & control*


  • Anti-Inflammatory Agents, Non-Steroidal
  • Ethanol
  • Capsaicin
  • Indomethacin