Can the Mediterranean diet lower HbA1c in type 2 diabetes? Results from a randomized cross-over study

Nutr Metab Cardiovasc Dis. 2011 Sep;21(9):740-7. doi: 10.1016/j.numecd.2010.03.005. Epub 2010 Jul 31.

Abstract

Background and aims: To investigate the impact of a diet modeled on the traditional Cretan Mediterranean diet on metabolic control and vascular risk in type 2 diabetes.

Methods and results: Twenty-seven subjects (47-77 yrs) with type 2 diabetes were randomly assigned to consume either the intervention diet ad libitum or their usual diet for 12 weeks and then cross over to the alternate diet. Most of the meals and staple foods for the intervention diet were provided. Lipids, glycemic variables, blood pressure, homocysteine, C-reactive protein, plasma carotenoids and body composition (anthropometry and dual energy X-ray absorptiometry) were assessed at baseline, and at the end of both diet periods. Dietary adherence was monitored using plasma carotenoid and fatty acid (FA) analysis, complemented by diet diaries. Compared with usual diet, on the ad libitum Mediterranean intervention diet glycosylated haemoglobin fell from 7.1% (95% CI: 6.5-7.7) to 6.8% (95% CI: 6.3-7.3) (p=0.012) and diet quality improved significantly [plant:animal (g/day) food ratio increased from 1.3 (95% CI: 1.1-1.5) to 5.4 (95% CI: 4.3-6.6) (p<0.001)], plasma lycopene and lutein/zeaxanthin increased (36% and 25%, respectively), plasma saturated and trans FAs decreased, and monounsaturated FAs increased.

Conclusion: A traditional moderate-fat Mediterranean diet improves glycemic control and diet quality in men and women with well-controlled type 2 diabetes, without adverse effects on weight.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Absorptiometry, Photon
  • Aged
  • Anthropometry
  • Biomarkers / blood
  • Blood Glucose
  • Blood Pressure / drug effects
  • Body Composition
  • C-Reactive Protein / metabolism
  • Carotenoids / blood
  • Cross-Over Studies
  • Diabetes Mellitus, Type 2 / diet therapy*
  • Diabetes Mellitus, Type 2 / genetics
  • Diet, Mediterranean*
  • Fatty Acids / blood
  • Female
  • Glycated Hemoglobin A / analysis
  • Glycated Hemoglobin A / drug effects*
  • Glycated Hemoglobin A / genetics*
  • Glycated Hemoglobin A / metabolism
  • Homocysteine / blood
  • Humans
  • Lipids / blood
  • Lutein / blood
  • Lycopene
  • Male
  • Middle Aged
  • Patient Compliance
  • Surveys and Questionnaires
  • Xanthophylls / blood
  • Zeaxanthins

Substances

  • Biomarkers
  • Blood Glucose
  • Fatty Acids
  • Glycated Hemoglobin A
  • Lipids
  • Xanthophylls
  • Zeaxanthins
  • hemoglobin A1c protein, human
  • Homocysteine
  • Carotenoids
  • C-Reactive Protein
  • Lycopene
  • Lutein