Prostaglandin E1 for the treatment of primary non-function of the donor organ in liver transplantation

Med J Aust. 1991 Jul 1;155(1):51-3. doi: 10.5694/j.1326-5377.1991.tb116384.x.


Objective: To present a case in which acute failure of a liver graft was treated with an infusion of prostaglandin E1 (PGE1).

Clinical features: A nine-year-old girl underwent liver transplantation for Wilson's disease. Her course was complicated by primary non-function of the graft as evidenced by poor bile production, rising bilirubin and liver enzyme levels and a severe coagulopathy.

Intervention and outcome: PGE1 was infused and there was recovery of graft function. The need for urgent re-transplantation was avoided.

Conclusions: PGE1 may have an important role in liver transplantation considering the logistic difficulties of obtaining donor livers for urgent transplantation in Australia.

Publication types

  • Case Reports

MeSH terms

  • Alprostadil / therapeutic use*
  • Child
  • Female
  • Host vs Graft Reaction / drug effects*
  • Humans
  • Liver Function Tests
  • Liver Transplantation*


  • Alprostadil