Review
doi: 10.1016/j.idc.2010.07.001.
Antiviral drug resistance: mechanisms and clinical implications
Affiliations
- PMID: 20674805
- DOI: 10.1016/j.idc.2010.07.001
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Review
Antiviral drug resistance: mechanisms and clinical implications
Infect Dis Clin North Am.
2010 Sep.
Erratum in
- Infect Dis Clin North Am. 2010 Sep;24(3):xi
Abstract
Antiviral drug resistance is an increasing concern in immunocompromised patient populations, where ongoing viral replication and prolonged drug exposure lead to the selection of resistant strains. Rapid diagnosis of resistance can be made by associating characteristic viral mutations with resistance to various drugs as determined by phenotypic assays. Management of drug resistance includes optimization of host factors and drug delivery, selection of alternative therapies based on knowledge of mechanisms of resistance, and the development of new antivirals. This article discusses drug resistance in herpesviruses and hepatitis B.
Copyright 2010 Elsevier Inc. All rights reserved.
Corrected and republished from
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Antiviral drug resistance: mechanisms and clinical implications.Infect Dis Clin North Am. 2010 Jun;24(2):413-37. doi: 10.1016/j.idc.2010.01.001. Infect Dis Clin North Am. 2010. Corrected and republished in: Infect Dis Clin North Am. 2010 Sep;24(3):809-33. doi: 10.1016/j.idc.2010.07.001. PMID: 20466277 Free PMC article. Corrected and republished. Review.
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